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Health

Tel Aviv hospital cures 29 of 30 COVID-19 patients in days, it says – The Jerusalem Post

Twenty-nine out of 30 moderate-to-severe COVID-19 sufferers who have been administered a therapy developed by Tel Aviv Sourasky Medical Heart (Ichilov Hospital) as a part of a Part I trial recovered from the illness and have been launched from the hospital inside three to 5 days, the hospital stated Friday.

The 30th affected person additionally recovered however it took longer.

The sufferers got Prof. Nadir Arber’s EXO-CD24 COVID-19 therapy, which relies on CD24-enriched exosomes and is supposed to combat the cytokine storm that’s related to most of the world’s COVID-19 deaths.

A cytokine storm is when the immune system primarily goes into overdrive and begins attacking wholesome cells. Exosomes are accountable for cell-to-cell communication. On this case, the exosomes ship the CD24 protein to the lungs, which helps settle down the immune system.

“This protein is positioned on the floor of cells and has a well known and necessary function in regulating the immune system,” defined Dr. Shiran Shapira, who works in Arber’s lab.

Arber has been researching exosomes for the higher a part of 20 years. He stated it took about six months from the time the concept of utilizing this therapy within the battle in opposition to COVID-19 was raised till it was first examined in people. 

The therapy is inhaled as soon as a day for a couple of minutes at a time for 5 days. It straight targets the lungs, the positioning of the storm, versus different remedies that could possibly be given systemically and therefore trigger extreme uncomfortable side effects, Arber defined.

The vast majority of the sufferers who acquired EXO-CD24 confirmed important enchancment inside two days.

The hospital has appealed to the Well being Ministry to maneuver ahead with additional medical trials. As soon as accredited, the therapy might be tried on extra sufferers.Prof. Nadir Arber (Credit: Ichilov Hospital)Prof. Nadir Arber (Credit score: Ichilov Hospital)

“That is an modern therapy that may be produced rapidly and effectively at a low value,” Arber defined. “Even when the vaccines do what they’re purported to, and even when no new mutations are produced, then nonetheless, in a method or one other, coronavirus will stay with us.”

The top of Suourasky, Prof. Ronni Gamzu hailed the treatment as “modern and complicated” and stated that the outcomes of the Part I trial “give us all an expression of confidence within the methodology.” He added that he would personally help Arber in acquiring the approvals wanted from the Well being Ministry to additional his analysis.
Gazmu served as Israel’s coronavirus commissioner from August to November 2020. He stated that the worldwide understanding is that alongside vaccines “it’s particularly necessary to develop medication to deal with the illness..”I’m proud that Ichilov … is probably bringing a blue-and-white resolution to a horrible world pandemic,” he concluded. 

This isn’t the primary Israeli drug to point out promise within the therapy of COVID-19. 

Final 12 months, Hadassah-University Medical Center reported similar results from the usage of the drug Allocetra, which was developed by the Enlivex Firm primarily based on analysis by a Hadassah physician, Prof. Dror Mevorach. Much like EXO-CD24, Allocetra is supposed to deal with the overreaction of the immune system.Additionally, Israel’s Pluristem Therapeutics has been investigating the usage of its PLX-PAD placenta-derived mobile remedy, which the corporate has stated it hopes will play a significant function in mitigating the tissue-damaging results of COVID-19 on the lungs. The corporate is now engaged in medical trials, as effectively.

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